1887

Abstract

SUMMARY: When yeast cells were incubated for 4 to 8 h in yeast extract-peptone-glucose medium, pH 6, containing 8 mM-manganese, and then plated on selective media, there was a strong induction of antibiotic-resistant mutations. Indirect evidence suggests that practically all resistant mutants selected were of independent origin. The analysis of manganese-induced resistant mutants showed that most were extranuclear, while those tested showed recombination with known mitochondrial markers.

Our results suggest that manganese can be considered as a mutagen which specifically induces mitochondrial mutations in

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/content/journal/micro/10.1099/00221287-90-2-265
1975-10-01
2020-01-29
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-90-2-265
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