Genetic Analysis of Valine Inhibition in the K12 Strain of Bacterium coli

SUMMARY: Development of resistance to valine by the K12 strain of Bacterium coli (Escherichia coli) has been found to occur by a one-step process leading to full resistance in every case. The genetic factors controlling this valine resistance have been studied by recombinant analyses. The results indicate a very close linkage between valine resistance and leucine independence. These substances have previously been shown to bear special relationship to each other with respect to the K12 strain.