1887

Abstract

SUMMARY: Sera of rabbits immunized with pili or formalized cultures of contained pili antibodies. The reaction between pili and specific gamma globulin was followed by direct visual observation with an electron microscope. Using pili from 31 strains and antisera against three strains, only a few cross-reactions between pili were observed. From this it is concluded that gonococcal pili are antigenically heterogeneous. However, serum raised with a T3 culture (with no detectable pili) contained antibodies against pili of the homologous T2 strain. It is proposed that the pilus antigen may exist in a form different from the typical pilus in gonococci.

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/content/journal/micro/10.1099/00221287-89-1-87
1975-07-01
2021-10-25
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References

  1. Almeida J. D., Waterson A. P. 1969; The morphology of virus-antibody interaction. Advances in Virus Research 15:307–338
    [Google Scholar]
  2. Arko R. J. 1972; Neisseria gonorrhoeae: experimental infection in laboratory animals. Science; New York: 177:1200–1201
    [Google Scholar]
  3. Buchanan T. M., Swanson J., Holmes K. K., Kraus S. J., Gotschlich E. C. 1973; Quantitative determination of antibody to gonococcal pili. Journal of Clinical Investigation 52:2896–2909
    [Google Scholar]
  4. Difco Manual, 7th edn.. 1971 pp. 122–123 Detroit: Difco Laboratories;
  5. Jephcott A. E., Reyn A., Birch-Andersen A. 1971; Neisseria gonorrhoeae. II. Demonstration of presumed appendages to cells from different colony types. Actapathologica et microbiologica scandinavica B79:437–439
    [Google Scholar]
  6. Kellogg D. S., Peacock W. L.JUN. Deacon W. E., Brown L., Pirkle C. I. 1963; Neisseria gonorrhoeae. I. Virulence genetically linked to clonal variation. Journal of Bacteriology 85:1274–1279
    [Google Scholar]
  7. Lawn A. M., Meynell E. 1970; Serotypes of sex pili. Journal of Hygiene 68:683–694
    [Google Scholar]
  8. Novotny P., Short J. A. L., Walker P. D. 1975; An electron microscope study of naturally occurring and cultured cells of Neisseria gonorrhoeae. Journal of Medical Microbiology (in the Press)
    [Google Scholar]
  9. Swanson J. 1973; Studies on gonococcus infection. IV. Pili: their role in attachment of gonococci to tissue culture cells. Journal of Experimental Medicine 137:571–589
    [Google Scholar]
  10. Turner W. H., Novotny P. 1974; Immune electron microscopy of Neisseria gonorrhoeae pili. Proceedings of the Society of General Microbiology 218
    [Google Scholar]
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