1887

Abstract

SUMMARY: Primaquin specifically inhibits mitochondrial function in yeast. Mutants resistant to primaquin have been isolated. Genetic analysis revealed that the expression of resistance in one of them was under the control of both a nuclear gene and a cytoplasmic factor (possibly a mitochondrial gene).

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-89-1-1
1975-07-01
2022-01-22
Loading full text...

Full text loading...

/deliver/fulltext/micro/89/1/mic-89-1-1.html?itemId=/content/journal/micro/10.1099/00221287-89-1-1&mimeType=html&fmt=ahah

References

  1. Al-Aidros K., Somers J. M., Bussey H. 1973; Retention of cytoplasmic killer determinants in yeast cells after removal of mitochondrial DNA by ethidium bromide. Molecular General Genetics 122:323–331
    [Google Scholar]
  2. Avner P. R., Coen D., Dujon B., Slonimski P. P. 1973; Mitochondrial genetics. IV. Allelism and map-ping studies of oligomycin resistance in Saccharomyces cerevisiae. Molecular General Genetics 125:9–53
    [Google Scholar]
  3. Avner P. R., Griffiths D. E. 1973; Genetic analysis of oligomycin resistant mutant of Saccharomyces cerevisiae. European Journal of Biochemistry 32:312–321
    [Google Scholar]
  4. Bolotin M., Coen D., Deutsch J., Dujon B., Netter P., Petrochilo E., Slonimski P. P. 1971; La recombinaison des mitochondries chez Saccharomyces cerevisiae. Bulletin Institut Pasteur 69:215–239
    [Google Scholar]
  5. Carnevali F., Leoni L. 1972; Intramolecular heterogeneity of yeast mitochondrial DNA. Biochemical and Biophysical Research Communications 47:1322–1331
    [Google Scholar]
  6. Clavillier L. 1962; Thèse, Faculté des Sciences Paris.
    [Google Scholar]
  7. Ephrussi B. 1953 Nucleocytoplasm Relation in Microorganisms Oxford: Blackwell;
    [Google Scholar]
  8. Ephrussi B., Jakob H., Granschamp S. 1966; Étude de la suppressivitè des mutants à déficience respiratoire de la levure. Genetics 54:1–29
    [Google Scholar]
  9. Goldring E. S., Grossmann L. I., Krupnick D., Cryer D. R., Marmur J. 1970; The petite mutation in yeast. Loss of mitochondrial desoxyribonucleic acid during interaction of petites with ethidium bromide. Journal of Molecular Biology 52:323–335
    [Google Scholar]
  10. Goldring E. S., Grossmann L. I., Marmur J. 1971; Petite mutation in yeast. II. Isolation of mutants containing mitochondrial desoxyribonucleic acid of reduced size. Journal of Bacteriology 107:377–381
    [Google Scholar]
  11. Howell N., Trembath M. K., Linnane A. W., Lukins H. B. 1973; An analysis of polarity of mitochondrial gene recombination and transmission. Molecular General Genetics 122:37–51
    [Google Scholar]
  12. Lacroute F. 1971; Non-Mendelian mutation allowing ureidosuccinic acid uptake in yeast. Journal of Bacteriology 106:519–522
    [Google Scholar]
  13. Mahler M. T., Mehrotra B. D., Perlman P. S. 1971; Ethidium bromide as a probe for the function of mitochondrial DNA. Progress in Molecular and Subcellular Biology 2:274
    [Google Scholar]
  14. Mehrotra BB. D., Mahler H. R. 1968; Characterization of some unusual DNAs from the mitochondria, from certain ‘petite’ strains of Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics 128:685
    [Google Scholar]
  15. Mounolou J. C., Jacob H., Slonimski P. P. 1966; Mitochondrial DNA from yeast ‘petite’ mutants. Specific changes of buoyant density corresponding to different cytoplasmic mutations. Biochemical and Biophysical Research Communications 24:218
    [Google Scholar]
  16. Nagley P., Linnane A. W. 1970; Mitochondrial DNA deficient petite mutants of yeast. Biochemical and Biophysical Research Communications 39:989–996
    [Google Scholar]
  17. Nagley P., Linnane A. W. 1972; Biogenetics of mitochondria: studies of the nature of the mitochondrial genome in yeast: the degenerative effects of ethidium bromide on mitochondrial genetic information in a respiratory competent strain. Journal of Molecular Biology 66:181–193
    [Google Scholar]
  18. Perlman P. S., Mahler H. R. 1971; Molecular consequences of ethidium bromide mutagenesis. Nature New Biology 231:12
    [Google Scholar]
  19. Rotman A. 1971; Effet de la primaquin sur les mitochondries de la levure, sélection de mutants resistant. Comptes rendus hebdomadaire des séances de I’Académie des sciences 272:3138
    [Google Scholar]
  20. Sainsard A. 1973; Thèse de 3ème Cycle, Orsay, France.
    [Google Scholar]
  21. Stuart K. D. 1970; Cytoplasmic inheritance of oligomycin and rutamycin resistance in yeast. Biochemical and Biophysical Research Communications 39:1045–1051
    [Google Scholar]
  22. Tilney-Bassett R. A. E. 1973; The control of plasmid inheritance in pelargonium II. Heredity 30:1–13
    [Google Scholar]
  23. Wolf K., Dujon B., Slonimski P. P. 1973; Mitochondrial genetics. V. Multifactorial mitochondrial crosses involving a mutation conferring paromomycin resistance in Saccharomyces cerevisiae. Molecular General Genetics 125:53–90
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-89-1-1
Loading
/content/journal/micro/10.1099/00221287-89-1-1
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error