SUMMARY: Strains of varied in their ability to elicit (in mice) an antibody bactericidal for an antiserum-sensitive strain of although antibody was usually detectable after only one injection. High titres were produced a course of seven injections with all strains of tested (six of phase I and three of phase IV) but not with three strains of other Bordetella species nor with two unrelated organisms, a finding of possible taxonomic value. Preliminary investigations have not revealed whether strain variations are due to quantitative or qualitative differences in either the bacterial lipopolysaccharide or the carrier protein necessary for antibody production, or whether they may be due to differences in heat lability of ‘bactericidal antigen’.


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