SUMMARY: Resistance to chloramphenicol was successfully transferred from strains of carrying R factors representative of compatibility groups F, W, S and N to strains of and Resistance to kanamycin was transferred from an R factor in group S, and to neomycin from an R factor of group P. Myxobacterial strains differed in their capacity to take up the resistances and also in the stability of the resistance character. Strains of were obtained that acquired resistance to chloramphenicol without exposure to R eubacterial strains. Cell-free preparations of all the chloramphenicol-resistant strains catalysed the acetylation of the drug. Chloramphenicol resistance was successfully transferred from the presumed R strains of Myxococcus and also from the spontaneously occurring chloramphenicol-resistant to other Myxococcus strains. Moreover, recombinants resistant to both rifampicin and 5-fluorouracil were obtained, though infrequently, mixing Myxococcus strains resistant to rifampicin and chloramphenicol with other myxococci resistant to 5-fluorouracil, both when the chloramphenicol resistance was derived from S-a (group W) and when it was the endogenous resistance. Thus it appears that S-a and a new chloramphenicol resistance factor from will mobilize a chromosomal genetic marker in Myxococcus.


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