Summary: The saprophytic cryptococci, and which are characterized by inability to grow at 37 °C and above, were shown to lyse at non-permissive growth temperatures. Incorporation of radioactive precursors of protein, RNA and DNA by suggested that protoplasmic growth continued at 37 °C. Incorporation of 20% sucrose in the growth medium retarded lysis at the non-permissive temperature and direct microscopic examination of cells under these conditions revealed aberrations in the walls and protoplast extrusion. Similar wall aberrations which were induced by the inhibitor 2-deoxyglucose suggest that aberrant wall biosynthesis occurs at non-permissive growth temperatures.


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