RT Journal Article SR Electronic(1) A1 Calcott, P. H. A1 Postgate, J. R.YR 1974 T1 The Effects of β-Galactosidase Activity and Cyclic AMP on Lactose-accelerated Death JF Microbiology, VO 85 IS 1 SP 85 OP 90 DO https://doi.org/10.1099/00221287-85-1-85 PB Microbiology Society, SN 1465-2080, AB SUMMARY: Lactose-limited chemostat populations of Klebsiella aerogenes 418 showed hyper-β-galactosidase activity after 170 generations. Within the normally active phase, hyperactivity could be induced by adding thiomethyl-β-d-galactoside and was lost on its removal; natural hyper-activity was lost on transfer to a lactose medium in which ammonium was limiting. The ability of lactose to accelerate death from starvation was proportional to the β-galactosidase activity of the population. Cyclic AMP in the recovery medium alleviated lactose-accelerated death. Suppression of adenyl cyclase activity by traumatic substrates may be responsible for substrate-accelerated death., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-85-1-85