@article{mbs:/content/journal/micro/10.1099/00221287-85-1-85, author = "Calcott, P. H. and Postgate, J. R.", title = "The Effects of β-Galactosidase Activity and Cyclic AMP on Lactose-accelerated Death", journal= "Microbiology", year = "1974", volume = "85", number = "1", pages = "85-90", doi = "https://doi.org/10.1099/00221287-85-1-85", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-85-1-85", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "SUMMARY: Lactose-limited chemostat populations of Klebsiella aerogenes 418 showed hyper-β-galactosidase activity after 170 generations. Within the normally active phase, hyperactivity could be induced by adding thiomethyl-β-d-galactoside and was lost on its removal; natural hyper-activity was lost on transfer to a lactose medium in which ammonium was limiting. The ability of lactose to accelerate death from starvation was proportional to the β-galactosidase activity of the population. Cyclic AMP in the recovery medium alleviated lactose-accelerated death. Suppression of adenyl cyclase activity by traumatic substrates may be responsible for substrate-accelerated death.", }