RT Journal Article SR Electronic(1) A1 Leisinger, T. A1 O’Sullivan, Christine A1 Haas, D.YR 1974 T1 Arginine Analogues: Effect on Growth and on the First Two Enzymes of the Arginine Pathway in Pseudomonas aeruginosa JF Microbiology, VO 84 IS 2 SP 253 OP 260 DO https://doi.org/10.1099/00221287-84-2-253 PB Microbiology Society, SN 1465-2080, AB Summary: The effect of 14 arginine analogues on the growth of Pseudomonas aeruginosa in a liquid mineral medium with either l-glutamate or l-ornithine as the sole carbon and nitrogen source was investigated. Two analogues, l-indospicine and l-arginine hydroxamate, inhibited growth markedly. The former was most effective in the or-nithine medium and the latter only in the glutamate medium. The inhibition by arginine analogues of the first two enzymes of the arginine pathway, N-acetylglutamate synthetase and N-acetylglutamate 5-phosphotransferase, was studied. It was found that inhibition of these two feedback-sensitive enzymes did not correlate with inhibition of growth. O-(l-norvalyl-5)-isourea, which was a rather weak inhibitor of growth, was at least three times more active as an inhibitor of the enzymes than l-indospicine and l-arginine hydroxamate. These two analogues were about ten times less effective than l-arginine, the strongest inhibitor of both enzymes., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-84-2-253