1887

Abstract

SUMMARY: Starvation of baker’s yeast, , in 2% glycerol induces high levels of petite mutants. The rate of mutation is highest when exponential phase cells are used to inoculate the starvation medium. The starved cells are exceedingly sensitive to ethidium bromide mutagenesis. Cycloheximide and sodium nalidixate enhance starvation-induced mutation (although nalidixate reduces the ethidium bromide induction). Starvation-induced mutation is inhibited by rifampicin or erythromycin. The appearance of petite mutants is preceded by a fall in both o and mitochondrial DNA.

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1974-09-01
2022-01-22
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