1887

Abstract

SUMMARY

The polyene antibiotic candicidin is a potent antifungal agent acting upon the cell membrane of Destruction of selective permeability by polyenes allows cations to leak into the environment and permits the entry of protons to neutralize the charge so created, causing internal acidification. Quantitive studies on proton entry reveal that K leakage alone is not sufficient to account for the degree of acidification recorded. Extracts of untreated when acidified to the same extent, precipitated. Electron micrographs of candicidin treated C. cells confirm this precipitation.

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/content/journal/micro/10.1099/00221287-81-2-331
1974-04-01
2024-04-25
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References

  1. Caltrider P., Gottlieb D. 1961; Studies on the mode of action of filipin on S. cerevisiae. Transactions of the Illinois Academy of Science 54:189–196
    [Google Scholar]
  2. Cirrilo V., Harsch M., Lampen J. O. 1964; The action of polyene antibiotics on yeast cell membranes. Journal of General Microbiology 35:249–259
    [Google Scholar]
  3. Conway E., Downey A. 1950; The outer metabolic region of yeast cells. Biochemical Journal 47:347–360
    [Google Scholar]
  4. Edebo L. 1961; Disintegration by freeze pressing. II. Effects on fungi. Acta pathologica et microbiologica scandinavica 52:371–368
    [Google Scholar]
  5. Gale G. 1963; Cytology of C. albicans as influenced by drugs acting on the cytoplasmic membrane. Journal of Bacteriology 86:151–157
    [Google Scholar]
  6. Ghosh A., Ghosh J. 1962; Changes in the intracellular constituents on treatment with nystatin and amphotericin B. Annals of Biochemistry and Experimental Medicine 23:113–122
    [Google Scholar]
  7. Hammond S. M., Lambert P. A., Kliger B. N. 1974; The mode of action of polyene antibiotics; induced potassium leakage in C. albicans. Journal of General Microbiology 81:325–330
    [Google Scholar]
  8. Lampen J. O. 1966; Polyene antibiotics and membrane function. Symposia of the Society for General Microbiology 16:111–130
    [Google Scholar]
  9. Osteux R., Tran-Van-Ky, Biquet P. 1958; Contribution d’étude du mode d’action de la nystatinesur C. albicans. Comptesrendus des seances de l’Académie des sciences 247:2475–2479
    [Google Scholar]
  10. Scholz R., Schmitz H., Bucher T., Lampen J. O. 1959; Über die Wirkung von Nystatin auf Bäckerhefe. Biochemische Zeitschrift 331:71–74
    [Google Scholar]
  11. Venables P., Russell A. 1972; Some effects of nystatin on S. cerevisiae. Microbios 6:239–246
    [Google Scholar]
  12. Waksman S., Lechevalier C., Schaffner C. 1965; Candicidin and other polyene antibiotics. Bulletin of the World Health Organisation 33:219–246
    [Google Scholar]
  13. Zygmunt W. 1966; Intracellular loss of potassium in C. albicans after exposure to polyene antibiotics. Applied Microbiology 14:953–956
    [Google Scholar]
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