Summary: The polyene antibiotic candicidin is a potent antifungal agent acting upon the cell membrane of . Destruction of selective permeability by polyenes allows cations to leak into the environment and permits the entry of protons to neutralize the charge so created, causing internal acidification. Quantitive studies on proton entry reveal that K leakage alone is not sufficient to account for the degree of acidification recorded. Extracts of untreated , when acidified to the same extent, precipitated. Electron micrographs of candicidin treated cells confirm this precipitation.


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