%0 Journal Article %A Hammond, S. M. %A Lambert, P. A. %A Kliger, B. N. %T The Mode of Action of Polyene Antibiotics; Induced Potassium Leakage in Candida albicans %D 1974 %J Microbiology, %V 81 %N 2 %P 325-330 %@ 1465-2080 %R https://doi.org/10.1099/00221287-81-2-325 %I Microbiology Society, %X SUMMARY: With a liquid membrane potassium-sensitive electrode it was shown that lethal concentrations of the polyene antibiotics amphotericin B, candicidin and nystatin caused leakage of 90% of non-bound potassium ions from Candida albicans. Accurate and rapid determinations of rates of potassium leakage were made directly in suspensions of Candida. Leakage patterns for the three polyenes were very similar, suggesting a common site of action. Differences were noted in the rates of potassium efflux with organisms from cultures of differing ages. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-81-2-325