1887

Abstract

SUMMARY: Adaptive patterns for a vibrio indicate that the oxidation of phenylalanine to homogentisic acid by this organism may proceed by two different pathways, one through phenylpyruvic and phenylacetic acids and the other through tyrosine and -hydroxyphenylpyruvic acid. That the former pathway is used is confirmed by the isolation from metabolism fluids of the phenylhydrazone of phenylpyruvic acid. The vibrio does not appear to oxidize the side chains of phenylpropionic and phenylacetic acids before ring fission. The influence of cell suspension density on rates of oxidation of various highly polar compounds which may penetrate slowly into the cells has been studied.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-8-1-1
1953-03-01
2022-01-26
Loading full text...

Full text loading...

/deliver/fulltext/micro/8/1/mic-8-1-1.html?itemId=/content/journal/micro/10.1099/00221287-8-1-1&mimeType=html&fmt=ahah

References

  1. Corson B. B., Dodge R. A., Harris S. A., Hazen R. K. 1944 Organic Syntheses i p. 244 New York: John Wiley and Sons Inc;
    [Google Scholar]
  2. Evans W. C. 1947; Oxidation of phenol and benzoic acid by some soil bacteria. Biochem. J 41:373
    [Google Scholar]
  3. Evans W. C., Smith B. S. W. 1951; The oxidation of aromatic compounds by soil bacteria. Biochem. J 49:x
    [Google Scholar]
  4. Evans W. C., Smith B. S. W., Linstead R. P., Elvidge A. 1951; Chemistry of the oxidative metabolism of certain aromatic compounds by micro-organisms. Nature; Lond: 168772
    [Google Scholar]
  5. Happold F. C. 1950; The oxidation of aromatic rings by micro-organisms in metabolism. Biochem. Soc. Symp585
    [Google Scholar]
  6. Happold F. C., Key A. 1932; The bacterial purification of gasworks’ liquors.The action of the liquors on the bacterial flora of the sewage. J. Hyg., Camb 32:573
    [Google Scholar]
  7. Herbst R. M., Shemin D. 1944 Organic Syntheses II p. 519 New York: John Wiley and Sons Inc;
    [Google Scholar]
  8. Jones J. D., Smith B. S. W., Evans W. C. 1952; Homogentisic acid as an intermediate in the metabolism of tyrosine by the aromatic ring-splitting microorganisms. Biochem. J 51:xi
    [Google Scholar]
  9. Karlsson J. L., Barker H. A. 1948; Evidence against the occurrence of a tricarboxylic acid cycle in Azotobacter agilis. J. biol. Chem 175:913
    [Google Scholar]
  10. Kilby B. A. 1948; The bacterial oxidation of phenol to β-ketoadipic acid. Biochem. J 43:v
    [Google Scholar]
  11. Kilby B. A. 1951; The formation of β-ketoadipic acid by bacterial fission of aromatic rings. Biochem. J 49:671
    [Google Scholar]
  12. Kluyver A. J., Van Zijp J. C. M. 1951; The production of homogentisic acid out of phenylacetic acid by Aspergillus niger. Antonie van Leeuwenhoek J. Microbiol. Serol 17:47
    [Google Scholar]
  13. Rimington C. 1950; The interpretation of biochemical detail revealed in inborn errors. Biochem. Soc. Symp416
    [Google Scholar]
  14. Stanier R. Y. 1947; Simultaneous adaptation: a new technique for the study of metabolic pathways. J. Bact 54:539
    [Google Scholar]
  15. Stanier R. Y. 1950; Problems of bacterial oxidative metabolism. Bact. Rev 14:179
    [Google Scholar]
  16. Stanier R. Y., Sleeper B. O., Tsuchida M., Macdonald D. L. 1950; The bacterial oxidation of aromatic compounds. III. The enzymatic oxidation of catechol and protocatechuic acid to β-ketoadipic acid. J. Bact 59:137
    [Google Scholar]
  17. Suda M., Hayaishi O., Oda Y. 1950; Studies on enzymatic adaptation. Med. J. Osaka Univ 2:21
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-8-1-1
Loading
/content/journal/micro/10.1099/00221287-8-1-1
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error