SUMMARY: Acid-extractable proteins were obtained from by pH titration, and partially characterized. They differ from mammalian histones and from the proteins obtained from other yeasts by similar methods. The largest fraction, extracted at pH 2.2, appeared to be predominantly of cytoplasmic origin. Quantitative changes in this fraction have been followed through the cell cycle and mapped relative to DNA synthesis, nuclear division and cell division. The total amount of such protein/cell doubled about one-third of a cycle after cell division and at a quarter of a cycle before nuclear division. DNA synthesis did not correspond to these doubling times but was almost simultaneous with cell division.


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