SUMMARY: Growth of 107 on -alkanes (C, C or a mixture) completely repressed formation of acetyl-CoA carboxylase and partially repressed the fatty acid synthetase complex. As all fatty acids must then be derived directly from the substrate no matter what its chain length, the yeast must be able to elongate even-chain acids (C to C) and modify, by unknown reactions, odd-chain acids to give even-chain acids. Short-term control of fatty acid biosynthesis appears to be by long-chain (C or C) fatty acyl-CoA esters feedback-inhibiting the activities of both acetyl-CoA carboxylase and fatty acid synthetase. -Alkanes, -alcohol, free fatty acids or C and C acyl-CoA esters, had little or no effects on these enzymes. Extracts from -alkane-grown yeast inhibited the carboxylase in extracts from glucose-grown yeast, the pattern of inhibition being similar to that observed with hexadecyl-CoA.


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