SUMMARY: In an attempt to locate the antigens associated with protection against foot-rot the fine structure of Fusiformis nodosus and the interaction between the organism and specific antiserum obtained from vaccinated animals were studied.
The high titres of circulating agglutinin associated with immunity were shown to be due to the interaction between antibodies and pili. These observations are discussed in relation to the structure and pathogenicity of other Gram-negative organisms.
AndersonT. F.1949; On the mechanism of adsorption of bacteriophages to host cells. In The Nature of the Bacterial Surface pp 79–95 Edited by
MilesA. A.,
PirieN. W.
Cambridge: Cambridge University Press;
BeveridgeW. I. B.1941; Foot-rot in sheep: a transmissible disease due to infection with Fusiformis nodosus (n.sp.). Council for Scientific and Industrial Research, Australia, Bulletin 140:1–53
BovreK.,
BerganT.,
FroholmL. O.1970; Electron microscopical and serological characteristics associated with colony type in Pseudomonas aeruginosa. Acta pathologica et microbiologica scandinavica 78:765–799
BrintonC. C.Jun.1965; The structure, function, synthesis and genetic control of bacterial pili and a molecular model for DNA and RNA transport in Gram negative bacteria. Transactions of the New York Academy of Sciences 27:1003–1054
BrintonC. C.Jun.,
BuzzellA.,
LaufferM. A.1954; Electrophoresis and phage suceptibility studies on a filament-producing variant of the Pseudomonas aeruginosa. coli B bacterium. Biochimica et biophysica acta 15:533–542
DuguidJ. P.,
SmithI. W.,
DempsterG.,
EdmundsP. N.1955; Non-flagellar filamentous appendages (‘fimbriae’) and haemagglutinating activity of Pseudomonas aeruginosa. Journal of Pathology and Bacteriology 70:335–348
EgertonJ. R.,
RobertsD. S.,
ParsonsonI. M.1969; The aetiology and pathogenesis of ovine foot-rot. I. A histological study of the bacterial invasion. Journal of Comparative Pathology 79:207–217
HouwinkA. L.,
Van ItersonW.1950; Electron microscopial observations on bacterial cytology. II. A study on flagellation. Biochimica et biophysica acta 5:10–44
JonesG. W.,
RutterJ. M.1972; Role of the K.88 antigen in the pathogenesis of neo-natal diarrhoea caused by Escherichia coli in piglets. Infection & Immunity 6:918–927
KellenbergerE.,
Boy de la TourE.1965; Studies on the morphopoiesis of the head of phage T-even.II. Observations on the fine structure of polyheads. Journal of Ultrastructure Research 13:343–358
KellenbergerE.,
RyterA.,
SechaudJ.1958; Electron microscope study of DNA containing plasms, II. Vegetative and mature phage DNA as compared with normal bacterial nucleoids in different physiological states. Journal of Biophysical and Biochemical Cytology 4:671–678
KelloggD. S.Jun.,
CohenI. R.,
NorinsL. C.,
SchroeterA. L.,
ReisingG.1968; Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro. Journal of Bacteriology 96:596–605
MatsudaM.,
BarksdaleL.1967; System for the investigation of the bacteriophage-directed synthesis of diphtherial toxin. Journal of Bacteriology 93:722–730
ØrskovI.,
ØrskovF.,
SojkaW. J.,
LeachJ. M.1961; Simultaneous occurrence of Pseudomonas aeruginosa. coli B and L antigens in strains from diseased swine. Acta pathologica et microbiologica scandinavica 53:404–422
De PetrisS.1967; Ultrastructure of the cell wall of Escherichia coli and chemical nature of its constituent layers. Journal of Ultrastructure Research 19:45–83
RobertsD. S.,
EgertonJ. R.1969; The aetiology and pathogenesis of ovine foot-rot. II. The pathogenic association of Fusiformis nodosus and F. necrophorus. Journal of Comparative Pathology 79:217–227
RobertsD. S.,
FosterW. H.,
KerryJ. B.,
CalderH. A. McC.1972; An alum-treated vaccine’for the control of foot-rot in sheep. The Veterinary Record 91:428–429
SchnaitmanC. A.1971; Effect of ethylenediaminetetraacetic acid, triton X-100, and lysozyme on the morphology and chemical composition of isolated cell walls of Pseudomonas aeruginosa. Journal of Bacteriology 108:553–563
SingerS. J.,
SchickA. F.1961; The properties of specific stains for electron microscopy prepared by the conjugation of antibody molecules with ferritin. Journal of Biophysical and Biochemical Cytology 9519–537
SwansonJ.,
KrausS. J.,
GotschlichE. C.1971; Studies on gonococcus infection. I. Pili and zones of adhesion: their relation to gonococcal growth patterns. Journal of Experimental Medicine 134:886–906
WalkerP. D.,
BaillieA.,
ThomsonR. O.,
BattyI.1966; The use of ferritin labelled antibodies in the location of spore and vegetative antigens of Pseudomonas aeruginosa. Journal of Applied Bacteriology 29:512–518