SUMMARY: is a bacterium whose life cycle involves sphere-rod-sphere morphogenesis. The molecular mechanism of such cellular differentiation is unknown. It is not clear whether this is regulated by simple metabolic controls such as feedback inhibition or whether expression of the genome is implicated. The present study involves a comparison of RNAs synthesized throughout the life cycle by using competitive RNA-DNA hybridization. The results show that there are differences in the RNAs synthesized at different times. The RNA appears to fall into two general categories, with some sequences always present and other sequences found only at certain times. Morphogenesis thus involves differential transcription of the genome.


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