%0 Journal Article %A Todd, N. K. %A Casselton, Lorna A. %T Non-complementation and Recessiveness as Properties of Missense Suppressor Genes in the Fungus Coprinus %D 1973 %J Microbiology, %V 77 %N 1 %P 197-207 %@ 1465-2080 %R https://doi.org/10.1099/00221287-77-1-197 %I Microbiology Society, %X SUMMARY: Mutations in the acu-1 gene which lead to inability to use acetate as sole carbon source have been used to select recessive su+ gene mutations. Of five acu-1 alleles tested, two, designated acu-1–2 and acu-1–4, were suppressible. At least three different su + genes suppressed the acu-1–2 mutation and two su + genes suppressed the acu-1–4 mutation. All five su + mutations are completely allele specific and will only suppress the acu-1 mutation for which they were selected. On a glucose medium, where su + activity is not required for growth, presence of a su + gene depresses the growth rate. These two facts suggest that the su + genes act by causing translation errors. Although individually each su + gene is recessive in a su +/su - heterozygote, any two su + genes in a double heterozygote do not complement. Recessiveness and non-complementation are considered as properties of missense su + genes involving modified tRNA species and interpreted in terms of su + tRNA concentrations. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-77-1-197