SUMMARY: Mutations in the gene which lead to inability to use acetate as sole carbon source have been used to select recessive su gene mutations. Of five alleles tested, two, designated and , were suppressible. At least three different genes suppressed the mutation and two genes suppressed the mutation. All five mutations are completely allele specific and will only suppress the mutation for which they were selected. On a glucose medium, where activity is not required for growth, presence of a gene depresses the growth rate. These two facts suggest that the genes act by causing translation errors. Although individually each gene is recessive in a / heterozygote, any two genes in a double heterozygote do not complement. Recessiveness and non-complementation are considered as properties of missense genes involving modified tRNA species and interpreted in terms of tRNA concentrations.


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