1887

Abstract

Summary: The sensitivities of strains of to the filament inducing agents nalidixic acid, gentian violet, crystal violet and penicillin were examined. The strains used included those in which the gene is suppressed by and as well as strains in which the Lon phenotype is expressed. The sensitivity of the bacteria to agents which act on DNA was reduced when was suppressed, but the extent of the decrease in sensitivity was dependent on the mechanism by which suppression was effected. Sensitivity to penicillin, on the other hand, was reduced only in the strain and by a mechanism which appears to be independent of the direct suppression of model to account for these results indicates possible sites at which the and genes are expressed.

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/content/journal/micro/10.1099/00221287-76-2-429
1973-06-01
2021-10-26
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References

  1. Adler H. I., Hardigree A. A. 1965; Post-irradiation growth, division and recovery in bacteria. Radiation Research 25:92–102
    [Google Scholar]
  2. Alper T. 1957; Observations on bacterial growth and morphology shortly after irradiation and some remarks on the oxygen effect. In Advances in Radiobiology, Proceedings of the Fifth International Conference on Radiobiology pp 90–96 Edited by de Hevesy G. C., Forssberg A. G., Abbatt J. D. Edinburgh: Oliver and Boyd;
    [Google Scholar]
  3. Boyce R. P., Howard-Flanders P. 1964; Release of ultraviolet light-induced thymine dimers from DNA in E. coli k-12. Proceedings of the National Academy of Sciences of the United States of America 51:293–300
    [Google Scholar]
  4. Brown D., Gillies N. E. 1972; The relationship between filaments, killing and restoration in irradiated Escherichia coli strain b . Journal of General Microbiology 70:461–470
    [Google Scholar]
  5. Clark D. J. 1968; Regulation of deoxyribonucleic acid replication and cell division in Escherichia coli b/r. Journal of Bacteriology 96:1214–1224
    [Google Scholar]
  6. Donachie W. D. 1969; Control of cell division in Escherichia coli: experiments with thymine starvation. Journal of Bacteriology 100:260–268
    [Google Scholar]
  7. Donch J., Chung Y. S., Green M. H. L., Greenberg J., Warren G. 1971; Genetic analysis of sul mutants of Escherichia coli b . Genetical Research 17:185–193
    [Google Scholar]
  8. Donch J., Chung Y. S., Greenberg J. 1969; Locus for radiation resistance in Escherichia coli strain b/r. Genetics 61:363–370
    [Google Scholar]
  9. Donch J., Green M. H. L., Greenberg J. 1968; Interaction of the exr and lon genes in Escherichia coli . Journal of Bacteriology 96:1704–1710
    [Google Scholar]
  10. Farnsworth P. A., James R. 1972; An effect of the LON phenotype in Escherichia coli as indicated by the growth of amoebae of Dictyostelium discoideum . Journal of General Microbiology 73:447–454
    [Google Scholar]
  11. Green M. H. L., Donch J., Chung Y. S., Greenberg J. 1969; Effect of inhibition of DNA synthesis on u.v. sensitive bs strains of Escherichia coli . Genetical Research 14:111–119
    [Google Scholar]
  12. Green M. H. L., Greenberg J., Donch J. 1969; Effect of a recA gene on cell division and capsular polysaccharide production in a lon strain of Escherichia coli . Genetical Research 14:159–162
    [Google Scholar]
  13. Hartmann R., Holtje J-V., Schwarz U. 1972; Targets of penicillin action in Escherichia coli . Nature, London 235:426–428
    [Google Scholar]
  14. Helmstetter C. E., Pierucci O. 1968; Cell division during inhibition of deoxyribonucleic acid synthesis in Escherichia coli . Journal of Bacteriology 95:1627–1633
    [Google Scholar]
  15. Holland I. B., Tuckett S. 1972; Study of envelope proteins in E. coli cet and recA mutants by SDS acrylamide gel electrophoresis. Journal of Supramolecular Structure 1:77–97
    [Google Scholar]
  16. Howard-Flanders P., Boyce R. B. 1966; DNA repair and genetic recombination: studies on Escherichia coli defective in these processes. Radiation Research Supplement 6:156–184
    [Google Scholar]
  17. Inouye M. 1969; Unlinking of cell division from deoxyribonucleic acid replication in a temperature-sensitive deoxyribonucleic acid synthesis mutant of Escherichia coli . Journal of Bacteriology 99:842–850
    [Google Scholar]
  18. Kantor G. J., Deering R. A. 1968; Effect of nalidixic acid and hydroxyurea on division ability of Escherichia coli fil+ and lon strains. Journal of Bacteriology 95:520–530
    [Google Scholar]
  19. Leighton P. M. 1972; Gel electrophoresis of the cell envelope of a division mutant of Escherichia coli . Canadian Journal of Microbiology 18:1611–1614
    [Google Scholar]
  20. Leighton P. M., Donachie W. D. 1970; Deoxyribonucleic acid synthesis and cell division in a lon mutant of Escherichia coli . Journal of Bacteriology 102:810–814
    [Google Scholar]
  21. Mattern I. E., Zwenk H., Rörsch A. 1966; The genetic constitution of the radiation-sensititive mutant Escherichia coli b s-1 . Mutation Research 3:374–380
    [Google Scholar]
  22. Normark S., Westling B. 1971; Nature of the penetration barrier in Escherichia coli k-12; effect of macromolecular inhibition on penetrability in strains containing the env A gene. Journal of Bacteriology 108:45–50
    [Google Scholar]
  23. Rörsch A., Edelman A., Van Der Kamp C., Cohen J. A. 1962; Phenotypic and genotypic characterization of radiation sensitivity in Escherichia coli b . Biochimica et biophysica acta 61:278–289
    [Google Scholar]
  24. Rupp W. D., Howard-Flanders P. 1968; Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation. Journal of Molecular Biology 31:291–304
    [Google Scholar]
  25. Schwarz U., Asmus A., Frank H. 1969; Autolytic enzymes and cell division. Journal of Molecular Biology 41:419–429
    [Google Scholar]
  26. Setlow R. B., Carrier W. L. 1964; The disappearance of thymine dimers from DNA: an error-correcting mechanism. Proceedings of the National Academy of Sciences of the United States of America 51:226–231
    [Google Scholar]
  27. Van de Putte P., Westenbroek C., Rörsch A. 1963; The relationship between gene-controlled radiation resistance and filament formation in Escherichia coli . Biochimica et biophysica acta 76:247–256
    [Google Scholar]
  28. Walker J. R., Pardee A. B. 1968; Evidence for a relationship between deoxyribonucleic acid metabolism and septum formation in Escherichia coli . Journal of Bacteriology 95:123–131
    [Google Scholar]
  29. Walker J. R., Shafiq N. A., Allen R. G. 1971; Bacterial cell division regulation: physiological effects of crystal violet on Escherichia coli lon+ and lon strains. Journal of Bacteriology 108:1296–1303
    [Google Scholar]
  30. Witkin E. M. 1947; Genetics of resistance to radiation in Escherichia coli . Genetics 32:221–248
    [Google Scholar]
  31. Witkin E. M. 1961; Modification of mutagenesis initiated by ultraviolet light through post-treatment of bacteria with basic dyes. Journal of Cellular and Comparative Physiology 58:(Suppl 1)135–144
    [Google Scholar]
  32. Zusman D. R., Inouye M., Pardee A. B. 1972; Cell division in Escherichia coli: evidence for regulation of septation by effector molecules. Journal of Molecular Biology 69:119–136
    [Google Scholar]
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