1887

Abstract

Summary: Three antimicrobial nitroimidazole drugs (metronidazole, dimetridazole, and tinidazole) inhibit a range of Clostridia and the protozoan ; they have an identical site and mode of action as specific electron acceptors from the pyruvate phosphoroclastic reaction. Analogues of the drugs are compared and the structural requirements for activity explained. The nitrofuran (nitrofura-zone) probably has a different mechanism of action.

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/content/journal/micro/10.1099/00221287-76-1-135
1973-05-01
2022-01-20
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References

  1. Asnis R. E., Cohen F. B., Gots J. S. 1952; Studies on bacterial resistance to Furacin. Antibiotics and Chemotherapy 2:123–130
    [Google Scholar]
  2. Bushby S. R. M., Copp F. C. 1955; The antitrichomonal activity of amido-nitrothiazoles. Journal of Pharmacy and Pharmacology 7:112–117
    [Google Scholar]
  3. Cosar C., Julou L. 1959; Activité de l’(hydroxy-2-ethyl)-l-methyl-2-nitro-5-imidazole (8.823 R.P.) vis-à-vis des infections experimentales à Trichomonas vaginalis . Annales de l’lnstitut Pasteur 96:238–241
    [Google Scholar]
  4. Edwards D. I., Mathison G. E. 1970; The mode of action of metronidazole against Trichomonas vaginalis . Journal of General Microbiology 63:297–302
    [Google Scholar]
  5. Edwards D. I., Mathison G. E. 1973; Metronidazole: an antimicrobial drug which inhibits photosynthesis. Zeitschrift für Pflanzenphysiologie (in the press)
    [Google Scholar]
  6. Edwards D. I., Schoolar A. I. 1971; Inhibition of sugar synthesis and potentiation of chlorophyll degradation in sugar cane leaf tissue by metronidazole. Zeitschrift für Pflanzenphysiologie 64:73–76
    [Google Scholar]
  7. Felix H., Ouryoux C. 1962; Traitement de la lambliase par le Metronidazole. Presse Médicate 70:261321
    [Google Scholar]
  8. Freeman W. A., McFadzean J. A., Whelan J. P. F. 1968; Activity of metronidazole against experimental tetanus and gas gangrene. Journal of Applied Bacteriology 31:443–447
    [Google Scholar]
  9. Fuzi M., Czukas Z. 1970; Das antibakterielle Wirkungspektrum des Metronidazols. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene (Abteilung 1) 213:258–262
    [Google Scholar]
  10. Gest H. 1954; Oxidation and evolution of molecular hydrogen by micro-organisms. Bacteriological Reviews 18:43–73
    [Google Scholar]
  11. Hoffman K. 1953 In The Chemistry of Heterocyclic Compounds vol vi part 1 Edited by Weissberger W.
    [Google Scholar]
  12. Howes H. L., Lynch J. E., Kivlin J. L. 1970; Tinidazole – a new antiprotozoal agent: effect on trichomonas and other protozoa. Antimicrobial Agents and Chemotherapy261–266
    [Google Scholar]
  13. Lucas J. M. S. 1961; 1,2-dimethyl-5-nitroimidazole, 8595 R.P.I. Prophylactic activity against experimental histomoniasis in turkeys. Veterinary Record 73:465–7
    [Google Scholar]
  14. McCalla D. R., Reuvers A., Kaiser C. 1970; Mode of action of nitrofurazone. Journal of Bacteriology 104:1126–1134
    [Google Scholar]
  15. McCalla D. R., Reuvers A., Kaiser C. 1971; Breakage of bacterial DNA by nitrofuran derivatives. Cancer Research 31:2184–2188
    [Google Scholar]
  16. Miles A. A., Misra S. S. 1938; The estimation of the bactericidal power of the blood. Journal of Hygiene 38:732–749
    [Google Scholar]
  17. Miller M. W., Howes H. L., English A. R. 1970; Tinidazole – a potent new antiprotozoal agent. Antimicrobial Agents and Chemotherapy257–260
    [Google Scholar]
  18. Mortenson L. E., Valentine R. C., Carnahan J. C. 1962; An electron transfer factor from Clostridium pasteurianum . Biochemical and Biophysical Research Communications 7:448–452
    [Google Scholar]
  19. Mortenson L. E. 1963; Nitrogen fixation: role of ferredoxin in anaerobic metabolism. Annual Reviews of Microbiology 17:115–138
    [Google Scholar]
  20. Paul H. E., Paul M. F. 1964; The nitrofurans – chemotherapeutic properties. In Experimental Chemotherapy vol 2 pp 307–370 Edited by Schnitzer R. J., Hawking F.
    [Google Scholar]
  21. Powell S. J., McLeod I., Wilmot A. J., Elsdon-Drew R. 1966; Metronidazole in amoebic dysentery and hepatic liver abscess. Lancet ii:1329–1331
    [Google Scholar]
  22. Rabinowitz J. C., Pincer W. E. 1956; Purine fermentation by Clostridium cylindrosporum . Journal of Biological Chemistry 222:537–554
    [Google Scholar]
  23. Thornley J., Edwards D. I. 1973; Treatment of an unusual case of gas gangrene by metronidazole. Canadian Journal of Medicine (in the press)
    [Google Scholar]
  24. Umbreit W. W., Burris R. H., Stauffer J. F. 1964 Manometric Techniques Minneapolis: Burgess Publishing Co.;
    [Google Scholar]
  25. Wolfe R. S., O’Kane D. J. 1953; Co-factors of the phosphoroclastic reaction of Clostridium butyricum . Journal of Biological Chemistry 205:755–765
    [Google Scholar]
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