@article{mbs:/content/journal/micro/10.1099/00221287-75-1-75, author = "Coles, R. S.", title = "The Effect of Glutathione on the Growth of Fusobacterium polymorphum", journal= "Microbiology", year = "1973", volume = "75", number = "1", pages = "75-81", doi = "https://doi.org/10.1099/00221287-75-1-75", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-75-1-75", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "SUMMARY: Washed Fusobacterium polymorphum did not initiate growth under semi-anaerobic conditions unless reducing compounds were added to the medium. In the presence of glutathione or cysteine, however, cultures incubated under air achieved a turbidity twice that of anaerobic cultures. The increased growth occurred in a diauxic manner and was inhibited by several compounds that block oxidative phosphorylation or other oxidative reactions. Growth was not affected by inclusion of fermentative by-products in the medium. Flushing of the atmosphere with oxygen at the beginning of the second growth phase enhanced the rate of the increased growth. Fusobacterium polymorphum was capable of oxidizing glutathione under all growth conditions tested. The diauxie was apparently mediated by the oxidation of GSH by F. polymorphum. ", }