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SUMMARY: Twelve species of Mycoplasma, comprising 15 strains, were examined for proteolytic activity. Only Mycoplasma arthritidis, strains PG6 and PG27, liquefied gelatin. The active principle shows enzymatic properties, appears both intra- and extracellularly and attacks only denatured collagen being without effect on native collagen and elastic tissue. The value of proteolytic activity as a taxonomic marker is discussed.
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