%0 Journal Article %A Sundaram, T. K. %T Myo-inositol Catabolism in Salmonella typhimurium: Enzyme Repression Dependent on Growth History of Organism %D 1972 %J Microbiology, %V 73 %N 2 %P 209-219 %@ 1465-2080 %R https://doi.org/10.1099/00221287-73-2-209 %I Microbiology Society, %X SUMMARY: Biochemical and genetic evidence suggests that NADPH-dependent 2-keto-myo-inositol reductase and 2-keto-myo-inositol dehydratase are associated with myo-inositol catabolism in Salmonella typhimurium. When growth of this organism is initiated in salts medium containing citrate and inositol using a citrate-grown inoculum, ketoinositol reductase is virtually completely repressed. By contrast, when inositol-grown organisms are used as inoculum, a relatively high level of the enzyme is present in bacteria even after a 20-fold increase in mass in the citrate + inositol medium. Under these conditions, inositol is used for growth to a significant extent, and citrate is utilized to a lesser extent than when growth is started with citrate-grown organisms. Thus by varying the growth history of the organism, different biochemical phenotypes can be produced without any change in the genotype or in the immediate environmental conditions. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-73-2-209