SUMMARY: Flagellum morphogenesis in the slime mould, involves a sequence of events during which amoebae are changed into biflagellated cells; in a population of cells this transformation is nearly synchronous. In the present study a series of inhibitors thought to inhibit RNA and protein synthesis and microtubule assembly were added in an attempt to characterize the macromolecular events associated with this amoebo-flagellate transformation.

High concentrations of acriflavin and proflavin (50 μg/Uml) and lower concentrations of cycloheximide (5 to 10 μg/ml) blocked the morphogenetic process completely. Other reported inhibitors of RNA synthesis and microtubular assembly delayed the onset of flagellum formation for varying periods of time dependent upon the concentrations employed.


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