Summary: DNA synthesis in and strains of is strongly inhibited without delay by low doses of gamma-radiation. The synthesis that does occur in these strains appears to take place mainly on chromosomes that have not received a lethal hit. Low doses produce much less inhibition of DNA synthesis in and wild-type strains. We conclude that the gene product acts immediately, certainly before DNA replication, in the repair of lesions produced by gamma-irradiation. In bacteria the gene product is not required for continued DNA synthesis, although the synthesis which occurs in strains may be abnormal since it is not reflected in increased survival. The gene product is not necessary for continued DNA replication, suggesting that its time of action in repair may be at a later stage.


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