1887

Abstract

Summary: Polyoxin D is a strong inhibitor of growth and spore germination of This antibiotic inhibited the growth of both the yeast and mycelial forms of It caused some minor morphological alterations but did not decisively affect the pattern of dimorphic development. Polyoxin D is a powerful competitive inhibitor of chitin synthetase ( = 0·6 μM). Organisms growing at inhibitory concentrations of the antibiotic exhibited weakened walls that were susceptible to bursting.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-71-2-301
1972-07-01
2021-10-26
Loading full text...

Full text loading...

/deliver/fulltext/micro/71/2/mic-71-2-301.html?itemId=/content/journal/micro/10.1099/00221287-71-2-301&mimeType=html&fmt=ahah

References

  1. BARTNICKI-GARCIA S. (1963); Symposium on biochemical bases of morphogenesis in fungi. III. Mold-yeast dimorphism of Mucor.. Bacteriological Reviews 27: 293–304.
    [Google Scholar]
  2. BARTNICKI-GARCIA S. (1968a); Control of dimorphism in Mucor by hexoses: inhibition of hyphal morphogenesis.. Journal of Bacteriology 96:1586–1594
    [Google Scholar]
  3. BARTNICKI-GARCIA S. (1968b) Cell wall chemistry, morphogenesis, and taxonomy of fungi.. Annual Review of Microbiology 2287–108
    [Google Scholar]
  4. BARTNICKI-GARCIA S., LIPPMAN E. (1969) Fungal morphogenesis: Cell wall construction in Mucor rouxii.. Science Washington: 165302–304
    [Google Scholar]
  5. BARTNICKI-GARCIA S., LIPPMAN E. (1971); Apical localization of chitin synthetase in the hyphae of Mucor rouxii.. Bacteriological Proceedings p. 61
    [Google Scholar]
  6. BARTNICKI-GARCIA S., NELSON N. , COTA-ROBLES E. (1968); Electron microscopy of spore germination and cell wall formation in Mucor rouxii.. Archiv fur Mikrobiologie 63:242–255
    [Google Scholar]
  7. BARTNICKI-GARCIA S., NICKERSON W. J. (1962); Isolation, composition, and structure of cell walls of filamentous and yeast-like forms of Mucor rouxii.. Biochimica et biophysica acta 58:102–119
    [Google Scholar]
  8. DIXON M. (1953); The determination of enzyme inhibitor constants.. Biochemical Journal 55:170–171
    [Google Scholar]
  9. ENDO A., KAKIKI K., MISATO J. . (1970); Mechanism of action of the antifungal agent polyoxin D.. Journal of Bacteriology 104:189–196
    [Google Scholar]
  10. ISONO K., ASAHI K., SUZUKI S. . (1969); Studies on polyoxins, antifungal antibiotics. XII. The structure of polyoxins.. Journal of the American Chemical Society 91:7490–7505
    [Google Scholar]
  11. ISONO K., NAGATSU J., KAWASHIMA Y. , SUZUKI S. (1965); Studies on polyoxins, antifungal antibiotics. Part I. Isolation and characterization of polyoxins A and B.. Agricultural and Biological Chemistry 29:848–854
    [Google Scholar]
  12. ISONO K., NAGATSU J., KOBINATA K., SASAKI K., SUZUKI S. (1967); Studies on polyoxins, antifungal antibiotics. Part V. Isolation and characterization of polyoxins C, D, E, F, G, H and I.. Agricultural and Biological Chemistry 31:190–199
    [Google Scholar]
  13. JONES D., BACON S. D., FARMER V. C. , WEBLEY D. M. (1968); Lysis of cell walls of Mucor ramannianus Moller by a Streptomyces sp.. Antonie van Leeuwenhoek 34:173–182
    [Google Scholar]
  14. KELLER F. A., CABIB E. (1971); Chitin and yeast budding. Properties of chitin synthetase from Saccharo- myces carlsbergensis.. Journal of Biological Chemistry 246:160–166
    [Google Scholar]
  15. MCMURROUGH I., BARTNICKI-GARCIA S. (1971); Properties of a particulate chitin synthetase from Mucor rouxii.. Journal of Biological Chemistry 246:4008–4016
    [Google Scholar]
  16. MCMURROUGH I., FLORES-CARREON A., BARTNICKI-GARCIA S. (1971); Pathway of chitin synthesis and cellular localization of chitin synthetase in Mucor rouxii.. Journal of Biological Chemistry 246:3999–4007
    [Google Scholar]
  17. OHTA N., KAKIKI K., MISATO T. . (1970); Studies on the mode of action of polyoxin D. Part II. Effect of polyoxin D on the synthesis of fungal cell wall chitin.. Agricultural and Biological Chemistry 34:1224–1234
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-71-2-301
Loading
/content/journal/micro/10.1099/00221287-71-2-301
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error