@article{mbs:/content/journal/micro/10.1099/00221287-70-3-491, author = "Cunningham, L. V. and Kazan, B. H. and Kuwahara, S. S.", title = "Effect of Long-chain Fatty Acids on Some Trypanosomatid Flagellates", journal= "Microbiology", year = "1972", volume = "70", number = "3", pages = "491-496", doi = "https://doi.org/10.1099/00221287-70-3-491", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-70-3-491", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "SUMMARY: A long-chain fatty-acid fraction obtained from the marine alga, Ulva lactuca, as well as decanoic, dodecanoic and hexadecanoic acids at levels of 250 μg/ml induced lysis of various Trypanosomatidae. However, octanoic and cis-9-octa-decenoic acids at higher concentrations had no effect. Decanoic, dodecanoic and hexadecanoic acids at levels below 100 μg/ml inhibited motility of the promasti-gotes of Leishmania donovani and L. tropica, and the epimastigotes and trypo-mastigotes of Trypanosoma cruzi. Crithidia fasciculata was relatively resistant to fatty acids and was not affected by decanoic acid at this level. The lysis induced by the marine algal fatty acids and by decanoic and dodecanoic acids was preceded by the formation of rounded forms ofthehaemoflagellates which indicated the loss of membrane structure.", }