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SUMMARY: Cultures of 15 each newly isolated ethionine-resistant metJ and K regulatory mutants of Salmonella typhimurium were infected with an Escherichia coli F′lac episome with an amber (UAG) nonsense mutation in the lacZ gene. F′Lac+ ethio-nine-sensitive derivatives segregating Lac− bacteria were obtained from one metJ and one metK mutant. Genetical and physiological analysis showed that these derivatives had acquired amber suppressors active on the metJ and metK mutations, leading to the conclusion that the metJ and metK genes code for polypeptides. The possible roles of the metJ and K gene products are discussed in the light of these results.
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