SUMMARY: Two serologically unrelated strains of nodule bacteria produced two different polysaccharides, only one of which precipitated with antiserum to its parent bacterium. Both polysaccharides interfered with the multiplication of two bacteriophages in liquid cultures of the two bacterial strains, each of which was susceptible to only one of the two bacteriophages. One polysaccharide was slightly more effective than the other in interfering with multiplication of both bacteriophages: one phage was much more susceptible than the other to the interfering action of both polysaccharides. Crystallized pancreatic ribonuclease interfered with multiplication of bacteriophages much more strongly than did the polysaccharides. Neither the polysaccharides nor ribonuclease destroyed the phage particles.


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