1887

Abstract

SUMMARY: Ten antibiotics have been included in this study; eight of them were metabolic products of fungi isolated from soils of the Bagshot Sand type. Their stability in Bagshot Sand soils and in a neutral garden loam has been investigated. Some were more stable than others, the rate of inactivation varied from soil to soil, but all exhibited a fair degree of stability in some of the soils. Four types of inactivation could be distinguished: (1) The natural pH of the soil was sometimes that at which the antibiotic was intrinsical unstable; this was noted specially with albidin, frequentin, gliotoxin, penicillin and viridin. (2) Inactivation caused by some form of biological activity, indicated by less rapid inactivation in heattreated than in untreated soil, was observed with griseofulvin, mycophenolic acid and patulin. (3) Adsorption on the soil was noticeable only in the case of streptomycin, the only basic antibiotic studied: acid-washed sand was able to bind appreciable quantities of this antibiotic, (4) Some other form of inactivation, probably chemical in nature, was concerned in the inactivation of gladiolic acid, penicillin and streptomycin.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-7-3-4-295
1952-11-01
2022-01-16
Loading full text...

Full text loading...

/deliver/fulltext/micro/7/3-4/mic-7-3-4-295.html?itemId=/content/journal/micro/10.1099/00221287-7-3-4-295&mimeType=html&fmt=ahah

References

  1. Brian P. W. 1946; Production of gliotoxin by Penicillium, terlikowskii Zal. Trans. Brit, mycol. Soc 29:211
    [Google Scholar]
  2. Brian P. W., Curtis P. J., Hemming H. G. 1946; A substance causing abnormal development of fungal hyphae produced by Penicillium janczewskii Zal. Part I. Trans. Brit, mycol. Soc 29:173
    [Google Scholar]
  3. Brian P. W., Curtis P. J., Hemming H. G. 1948; Gladiolic acid, an antibiotic produced by Penicillium gladioli McCull & Thom. J. gen. Microbiol 2:341
    [Google Scholar]
  4. Brian P. W., Hemming H. G. 1945; Gliotoxin, a fungistatic metabolic product of Trichoderma viride. Ann. appl. Biol 32:214
    [Google Scholar]
  5. Brian P. W., Hemming H. G., McGowan J. C. 1945; Origin of a toxicity to mycorrhiza in Wareham Heath soil. Nature; Lond: 155637
    [Google Scholar]
  6. Brian P. W., McGowan J. C. 1945; Viridin: a highly fungistatic substance produced by Trichoderma viride. Nature; Lond: 156:144
    [Google Scholar]
  7. Curtis P. J., Grove J. F. 1947; A fungistatic and bacteriostatic red pigment produced by a strain of the Penicillium nigricans janczewskii series. Nature; Lond: 160574
    [Google Scholar]
  8. Curtis P. J., Hemming H. G., Smith W. K. 1951; Frequentin, an antibiotic produced by Penicillium frequentans Westling. Nature; Lond: 167:557
    [Google Scholar]
  9. Florey H. W., Chain E., Heatley N. G., Jennings M. A., Sanders A. G., Abraham E. P., Florey M. E. 1949 Antibiotics Oxford University Press;
    [Google Scholar]
  10. Foster J. W., Woodruff H. B. 1944; Microbiological aspects of penicillin. VI. Procedure for cup assay for penicillin. J. Bact 47:43
    [Google Scholar]
  11. Jefferys E. G., Smith W. K. 1951; A new type of soil percolator. Proc. Soc. appl. Bact 14:169
    [Google Scholar]
  12. Pramer D., Starkey R. L. 1951; Decomposition of streptomycin. Science 113:127
    [Google Scholar]
  13. Rayner M. C. 1945; Origin of toxicity to fungi in Wareham Heath soil. Nature; Lond: 156174
    [Google Scholar]
  14. Siminoff P., Gottlieb D. 1951; The production and role of antibiotics in the soil. I. The fate of streptomycin. Phytopathology 41:420
    [Google Scholar]
  15. Waksman S. A. 1949 Streptomycin, Nature and Practical Applications London: Baillière, Tindall and Cox;
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-7-3-4-295
Loading
/content/journal/micro/10.1099/00221287-7-3-4-295
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error