1887

Abstract

SUMMARY: Chloramphenicol did not inhibit growth and protein synthesis when added (100 g./ml.) to growing cultures of , even though the organism was sensitive to this antibiotic in plate assay. This paradox was explained by the finding that chloramphenicol was rapidly reduced and thus detoxified by actively growing cultures. Cell-free extracts of reduced the aryl nitro group of chloramphenicol via a ferredoxin-dependent enzymic reaction for which pyruvate was the most effective primary electron donor. A number of other aryl nitro-compounds were similarly reduced.

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/content/journal/micro/10.1099/00221287-67-3-265
1971-08-01
2022-01-18
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