Summary: Partially purified histidinol dehydrogenases from a variety of micro-organisms have been tested with antibodies prepared in rabbits to pure histidinol dehydrogenases (HD enzymes) from (NHD) and (SHD). Cross-reactions using the double diffusion technique were demonstrated only between the pairs and and and The dehydrogenation of histidinol by and was inhibited by their respective antibodies and antibody to NHD inhibited HD enzymes from and spinach in decreasing effectiveness. Antibody to SHD inhibited HD from , and to approximately the same degree and from to a lesser degree. HD activity from and was affected by neither of the antibodies.


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