1887

Abstract

SUMMARY: Wax D, a chloroform-soluble and boiling-acetone-insoluble fraction extracted from various human strains of mycobacteria, showed characteristic biological activities such as Freund-type adjuvant activity (Raffel, 1950; White, Jollès, Samour & Lederer, 1964) and the induction of adjuvant arthritis in rats (Pearson, 1959; Pearson, Wood, McDaniel & Daft, 1963). Wax D from human strains was found to be peptidoglycolipid consisting of unsaturated fatty acid (mycolic acid) esters of mucopolysaccharide containing a peptide moiety of alanine, glutamic acid and --'-diaminopimelic acid (Asselineau, 1951; Asselineau, Buc, Jollés & Lederer, 1958). Previous work from this laboratory has shown the importance of fatty acid content for the adjuvant activity of the wax D of a human strain, Peurois (Hiu, Amiel & Jollès, 1969). This communication reports an increase in adjuvant activity after hydrogenation of the fatty acids forming the lipid portion of the wax D from the human strains Peurois and Canetti.

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/content/journal/micro/10.1099/00221287-66-2-239
1971-05-01
2021-10-23
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References

  1. Asselineau J. 1951 Acides mycoliques et cires du bacille tuberculeux Thesis: University of Paris;
    [Google Scholar]
  2. Asselineau J., Buc H., Jollès P., Lederer E. 1958; Sur la structure d’une fraction peptido-glyco- lipidique (Cires D) isolee de M. tuberculosis var. hominis. Bulletin de la Société de Chimie Biologique 40:1953
    [Google Scholar]
  3. Brian B. L., Gardner E. W. 1968; Fatty acids from Vibrio cholerae lipids. Journal of Infectious Diseases 118:47
    [Google Scholar]
  4. Hiu I. J., Amiel J. L., Jollès P. 1969; Relation entre la teneur en lipides et l’activité adjuvante des Cires D, peptido-glycolipides de M. tuberculosis. Revue Frangaise d’études Cliniques et Biologiques 14:508
    [Google Scholar]
  5. Jollès P., Samour D., Lederer E. 1962; Analytical studies on wax D, a macromolecular peptidoglycolipid fraction from human strains of M. tuberculosis. Archives of Biochemistry and Biophysics Suppl 1:283
    [Google Scholar]
  6. Pearson C. M. 1959; Development of arthritis in rat following injection with adjuvant.. In Mechanism of Hypersensitivity p 647 Edited by Shaffer J. H., Lo Grippo G. A., Chase N. W. Boston: Little Brown;
    [Google Scholar]
  7. Pearson C. M., Wood F. D., McDaniel E. G., Daft F. S. 1963; Adjuvant arthritis induced in germ- free rats. Proceedings of the Society for Experimental Biology and Medicine 112:91
    [Google Scholar]
  8. Raffel S. 1950; Chemical factors involved in the induction of infections allergy. Experientia 6:410
    [Google Scholar]
  9. Vilkas-Tenenbaum E. 1960 Sur la structure chimique des phospholipides de quelques souches de mycobactèries Thesis: University of Paris; p 69
    [Google Scholar]
  10. White R. G., Jollès P., Samour D., Lederer E. 1964; Correlation of adjuvant activity and chemical structure of wax D fractions of mycobacteria. Immunology 7:158
    [Google Scholar]
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