SUMMARY: After growth of representatives of eight genera in the order Actinomycetales and two others related taxonomically to Mycobacterium under iron-deficient conditions, the following compounds were found in the media: salicylic and phenylacetic acids, but no mycobactin, with Thermoactinomyces vulgaris; 2,3-dihydroxybenzoic acid with Corynebacterium equi, Mycococcus sp., Nocardia opaca and Streptosporangium rubrum; a conjugate of 2,3-dihydroxybenzoic acid and 3,4-dihydroxybenzoic acid were also found with S. rubrum. Unidentified compounds giving a positive reaction to FeCl3 were found after growth of Dactylosporangium thailandensis and Propionibacterium shermanii. No iron-binding compounds were detected with Actinoplanes phillippinensis, Micromonospora sp. and Streptomyces albus.
BakshiY. K.,
WilliamsR. P.1969; Biosynthesis of protocatechuic acid by non-proliferating cells of Bacillus anthracis. Bacteriological Proceedings p 145
BrotN.,
GoodwinJ.,
FalesH.1966; In vivo and in vitro formation of 2,3-dihydroxybenzoylserine by Escherichia coli k 12. Biochemical and Biophysical Research Communications 25:454–461
ChaoK. C.,
HawkinsD.,
WilliamsR. P.1967; Production of protocatechuic acid by non-proliferating suspensions of Bacillus anthracis. Bacteriological Proceedings p 31
CorbinJ. L.,
BulenW. A.1969; The isolation and identification of 2,3-dihydroxybenzoic acid and 2-N6-N-Di-(2,3-dihydroxybenzoyl)-l-lysine formed by iron-deficient Azotobacter vinelandii. Biochemistry 8:757–762
DhopleA. M.,
MorrisonN. E.,
HanksJ. H.1965; Effect of iron limitation on the production of salicylic acid and bound hydroxylamine by Mycobacterium phlei. Bacteriological Proceedings p 56
DonaldC.,
PasseyB. J.,
SwabyR. J.1952; A comparison of methods for removing trace metals from microbiological media. Society for General Microbiology 7:211–220
DownerD. N.,
DavisW. B.,
ByersB. R.1970; Repression of phenolic acid-synthesizing enzymes and its relation to iron uptake in Bacillus subtilis. Journal of Bacteriology 101:181–187
DyerJ. R.,
HedingH.,
SchafferC. P.1964; Phenolic metabolite of ‘low-iron fermentation’ of Streptomyces griseus Characterization of 2,3-dihydroxybenzoic acid. Journal of Organic Chemistry 29:2802–2803
ItoT.,
NeilandsJ. B.1958; Products of ‘low-iron fermentation’ with Bacillus subtilis’. isolation, characterization and synthesis of 2,3-dihydroxybenzoylglycine. Journal of the American Chemical Society 80:4645–4647
KorthH.1970; Über das Vorkommen von 2,3-Dihydroxybenzoesäure und ihrer Aminosäurederivate in Kulturmedien von Klebsiella oxytoca. Archiv für Mikrobiologie 70:297–302
LukeR. H. J.1970; Studies on the biosynthesis of 2,3-dihydroxybenzoic acid and related compounds. in Escherichia colik 12. Ph.D Thesis The Australian National University; Canberra, Australia:
McGeerE. G.,
RobertsonM. C.,
McGeerP. L.1961; Chromatographic characteristics of some aromatic compounds of biological interest. Canadian Journal of Biochemistry and Physiology 96:605–627
O’BrienI. G.,
GibsonF.1970; The structure of enterochelin and related 2,3-dihydroxy-N-benzoyl serine conjugates from Escherichia coli. Biochimica et biophysica acta 215:393–402
PollackJ. R.,
NeilandsJ. B.1970; Enterobactin, an iron transport compound from Salmonella typhimurium. Biochemical and Biophysical Research Communications 38:989–992
RatledgeC.1964; Relationship between the products of aromatic biosynthesis in Mycobacterium smegmatis and Aerobacter aerogenes. Nature, London 203:428–429
RatledgeC.1967; The production of an iV-acylanthranilic acid from shikimic acid and the effect of iron deficiency on the biosynthesis of other aromatic compounds by Aerobacter aerogenes. Biochimica et biophysica acta 141:55–63
RatledgeC.,
WinderF. G.1962; The accumulation of salicylic acid by mycobacteria during growth on an iron-deficient medium. Biochemical Journal 84:501–506
RatledgeC.,
WinderF. G.1966; Biosynthesis and utilization of aromatic compounds by Mycobacterium smegmatis with particular reference to the origin of salicylic acid. Biochemical Journal 101:274–283
WangC. C.,
NewtonA.1969; Iron transport in Escherichia coli roles of energy-dependent uptake and 2,3-dihydroxybenzoylserine. Journal of Bacteriology 98:1142–1150
WhiteA. J.,
SnowG. A.1968; Methods for the separation and identification of mycobactins from various species of mycobacteria. Biochemical Journal 108:593–597