1887

Abstract

SUMMARY

F′ elements carrying wild-type alleles of the methionine regulatory genes and have been transferred from to and mutants of , and the resulting heterogenotes tested for resistance to methionine analogues and for repressibility of cystathionase (one of the methionine biosynthetic enzymes). The wild-type alleles of both genes were dominant in both tests. Increased gene dosage was found to have no effect on the rate of uptake of [C]methionine by cell suspensions. Possible roles for the and gene products in the regulation of methionine synthesis are considered.

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1970-09-01
2024-12-14
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References

  1. Ames G. F., Roth J. R. 1968; Histidine and aromatic permeases of Salmonella typhimurium . Journal of Bacteriology 96:1742–1749
    [Google Scholar]
  2. Ayling P. D., Chater K. F. 1968; The sequence of four structural and two regulatory methionine genes in the Salmonella typhimurium linkage map. Genetical Research 12:341–354
    [Google Scholar]
  3. Balbinder E. 1964; Intergeneric complementation between A and B components of bacterial tryptophan synthetases. Biochemical and Biophysical Research Communications 17:770–774
    [Google Scholar]
  4. Cantoni G. L. 1965; S-Adenosylmethionine revisited. In Transmethylation and Methionine Biosynthesis p. 21 Shapiro S. K., Schlenk F. Edited by University of Chicago Press.:
    [Google Scholar]
  5. Chater K. F. 1969 Linkage and Dominance Studies of Genes Controlling Methionine Synthesis in Salmonella typhimurium. Ph.D.Thesis Birmingham University:
    [Google Scholar]
  6. Chater K. F., Rowbury R. J. 1970; A genetical study of the feedback sensitive enzyme of methionine synthesis in Salmonella typhimurium . Journal of General Microbiology 63:111–120
    [Google Scholar]
  7. Childs J. D., Smith D. A. 1969; New methionine structural gene in Salmonella typhimurium . Journal of Bacteriology 100:377–382
    [Google Scholar]
  8. Cox R., Smith R. C. 1969; Inhibition of S-adenosylmethionine formation by analogues OF methionine. Archives of Biochemistry and Biophysics 129:615–619
    [Google Scholar]
  9. Fink G. R., Roth J. R. 1968; Histidine regulatory mutants in Salmonella typhimurium. VI. Dominance studies. Journal of Molecular Biology 33:547–557
    [Google Scholar]
  10. Greene R. C., Su C.-H., Holloway C. T. 1970; S-Adenosylmethionine synthetase deficient mutants of Escherichia coli K12 with impaired control of methionine biosynthesis. Biochemical and Biophysical Research Communications 38:1120–1126
    [Google Scholar]
  11. Gross T. S. 1969 Biochemical Aspects of the Regulation of Methionine Biosynthesis in Salmonella typhimurium. Ph.D. Thesis University College, London University.:
    [Google Scholar]
  12. Gross T. S., Rowbury R. J. 1969; Methionyl transfer RNA synthetase mutants of Salmonella typhimurium which have normal control of the methionine biosynthetic enzymes. Biochimica et Biophysica Acta 184:233–236
    [Google Scholar]
  13. Hirota Y. 1960; The effect of acridine dyes on mating type factors in Escherichia coli . Proceedings of the National Academy of Sciences of the United States of America 46:57–64
    [Google Scholar]
  14. Ito J. 1969; Hybrid anthranilate synthetase molecules from Enterobacterial sources. Nature; London: 22357–59
    [Google Scholar]
  15. Kaplan M. M., Flavin M. 1966; Cystathionine-γ-synthetase of Salmonella. Structural properties of a new enzyme in bacterial methionine biosynthesis. Journal of Biological Chemistry 241:5781–5789
    [Google Scholar]
  16. Lawrence D. A., Smith D. A., Rowbury R. J. 1968; Regulation of methionine synthesis in Salmonella typhimurium: mutants resistant to inhibition by analogues of methionine. Genetics, Princeton 58:473–492
    [Google Scholar]
  17. Lee L.-W., Ravel J. M., Shive W. 1966; Multimetabolite control of a biosynthetic pathway by sequential metabolites. Journal of Biological Chemistry 241:5479–5480
    [Google Scholar]
  18. Muller-HILL B., Crapo L., Gilbert W. 1968; Mutants that make more lac repressor. Proceedings of the National Academy of Sciences of the United States of America 59:1259–1264
    [Google Scholar]
  19. Okada M., Watanabe T., Miyake T. 1968; On the nature of the recipient ability of Salmonella typhimurium for foreign deoxyribonucleic acids. Journal of General Microbiology 50:241–252
    [Google Scholar]
  20. Piperno J. R., Oxender D. L. 1968; Amino acid transport systems in Escherichia coli KI2. Journal of Biological Chemistry 243:5914–5920
    [Google Scholar]
  21. Rowbury R. J. 1968; The inhibitory action of α-methylmethionine on Escherichia coli . Journal of General Microbiology 52:223–230
    [Google Scholar]
  22. Rowbury R. J., Woods D. D. 1964; Repression by methionine of cystathionase formation in Escherichia coli . Journal of General Microbiology 35:145–158
    [Google Scholar]
  23. Sanderson K. E. 1967; Revised linkage map of Salmonella typhimurium . Bacteriological Reviews 31:354–372
    [Google Scholar]
  24. Sanderson K. E., Demerec M. 1965; The linkage map OF Salmonella typhimurium . Genetics, Princeton 51:897–913
    [Google Scholar]
  25. Schlesinger S. 1967; Inhibition of growth of Escherichia coli and of homoserine-O-transsuccinylase by α-methylmethionine. Journal of Bacteriology 94:327–332
    [Google Scholar]
  26. Smith D. A. 1961; Some aspects of the genetics of methionineless mutants of Salmonella typhimurium . Journal of General Microbiology 24:335–353
    [Google Scholar]
  27. Smith D. A., Childs J. D. 1966; Methionine genes and enzymes OF Salmonella typhimurium . Heredity 21:265–286
    [Google Scholar]
  28. Smith H. O., Levine M. 1967; A phage P 22 gene controlling integration of prophage. Virology 31:207–216
    [Google Scholar]
  29. Spizek J., Janecek J. 1969; The effect of ethionine on the synthesis of β-galactosidase: formation of an immunologically cross-reacting protein. Biochemical and Biophysical Research Communications 34:17–21
    [Google Scholar]
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