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SUMMARY
F′ elements carrying wild-type alleles of the methionine regulatory genes metJ and K have been transferred from Escherichia coli to metJ and K mutants of Salmonella typhimurium, and the resulting heterogenotes tested for resistance to methionine analogues and for repressibility of cystathionase (one of the methionine biosynthetic enzymes). The wild-type alleles of both genes were dominant in both tests. Increased metK gene dosage was found to have no effect on the rate of uptake of [14C]methionine by cell suspensions. Possible roles for the metJ and K gene products in the regulation of methionine synthesis are considered.
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