1887

Abstract

SUMMARY

Exposure of growing to 1 g. isoniazid/ml. inhibited the incorporation of C from [U-C] and [2-C]glycerol and [1-C]- glutamate into its walls by about 50 % over 12 h. because C incorporation into the mycolic acids of the walls was prevented. Isoniazid, 0·5 g. / ml. with or 0·1 g./ml. with H37 Ra, inhibited incorporation of C from [U-C] glycerol into total mycolic acids by about 90 % over 6 h., indicating that inhibition began within 1 h. of the addition of the drug. There was no effect on mycolic acid synthesis in an isoniazid- resistant strain of . The primary inhibitory action of isoniazid in sensitive mycobacteria is probably on mycolic acid synthesis, and this leads to formation of defective boundary layers of the bacteria.

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1970-09-01
2021-10-23
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