Inhibition by D-Glutamate of Growth and Glutamate Dehydrogenase Activity of Free

Abstract

-Glutamic acid (-glu) inhibited strongly the growth of two strains of in a minimal medium. The inhibition was completely annulled by equivalent concentrations of -glutamic acid (-glu) or -gluta-mine. -G1u also inhibited glutamate dehydrogenase (GDH) and was only antagonized completely by 10 equivalents of -glu. -G1u in media containing -glu increased GDH-activity, presumably by de-repression. -G1u showed no effect on glutamine synthetase and γ-glutamyl transferase activities. Inhibition of growth of by -glu thus seems due to the interference with glutamate synthesis by inhibition of GDH-activity.

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1970-05-01
2024-03-28
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