1887

Abstract

SUMMARY

D-Glutamic acid (D-glu) inhibited strongly the growth of two strains of in a minimal medium. The inhibition was completely annulled by equivalent concentrations of L-glutamic acid (L-glu) or L-gluta-mine. D-Glu also inhibited glutamate dehydrogenase (GDH) and was only antagonized completely by 10 equivalents of L-glu. D-Glu in media containing L-glu increased GDH-activity, presumably by de-repression. D-Glu showed no effect on glutamine synthetase and γ-glutamyl transferase activities. Inhibition of growth of by D-glu thus seems due to the interference with glutamate synthesis by inhibition of GDH-activity.

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/content/journal/micro/10.1099/00221287-61-2-255
1970-05-01
2019-10-14
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-61-2-255
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