SUMMARY: Breakdown of DNA to acid-soluble fragments induced in strains of B by nalidixic acid (10 μg./ml.) differed in linear rate according to the ability of the strain to repair DNA lesions. Strains which were (BS-2) and (BS-1) exhibited excessive DNA breakdown following nalidixic acid treatment. The excision-defective strains, BS-8, BS-12 and wwp-2 , also degraded their DNA to acid-soluble fragments at a rate which initially was greater than that of the parental strain ( B). This degradation was unaffected by the mutation. Removal of nalidixic acid from the system considerably lowered the rate of DNA breakdown. The responses to nalidixic acid and other agents potentiating DNA breakdown are compared.


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