1887

Abstract

SUMMARY: Methionine-requiring mutants of produce large amounts of hydrogen sulphide from sulphate, sulphite or thiosulphate when grown in the presence of suboptimum concentrations of methionine. -Acetylhomoserine and homocysteine act like methionine with a methionine-requiring mutant which can use them for growth. Wild-type strains of and also form large amounts of hydrogen sulphide from inorganic sulphur sources when the yeast is deficient in either pantothenate or vitamin B. This excess sulphide production is inhibited by methionine or its immediate precursors, suggesting that both vitamins are required for methionine biosynthesis. -Acetylhomoserine is a normal precursor of homocysteine and methionine in and The effect of pantothenate on sulphide production by these yeasts is probably due to its involvement in the formation of -acetylhomoserine.

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/content/journal/micro/10.1099/00221287-61-1-107
1970-04-01
2022-05-25
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References

  1. Aida K., Tukoyama T., Uemura T. 1969; The role of cysteine desulphydrase and cysteine synthase in the evolution of hydrogen sulphide in pantothenic acid deficient yeast. Antonie van Leeuwenhoek 95: supplement: Yeast Symposium
    [Google Scholar]
  2. Botsford J. L., Parks L. W. 1969; Serine transhydroxymethylase in methionine biosynthesis in Saccharomyces cerevisiae . Journal of Bacteriology 97:1176
    [Google Scholar]
  3. Brenner M. W., Owades J. L., Golyzniak R. 1954; Determination of volatile sulphur compounds. Proceedings of the American Society of Brewing Chemists annual meeting 1953 p. 83 Madison, Wisconsin:
    [Google Scholar]
  4. Cherest H., Eichler F., De Robichon-Szulmajster H. 1969; Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae . Journal of Bacteriology 97:328
    [Google Scholar]
  5. Davis B. D., Mingioli E. S. 1950; Mutants of Escherichia coli requiring methionine or vitamin B12 . Journal of Bacteriology 60:17
    [Google Scholar]
  6. Derobichon-Szulmajster H. 1967; Régulation du fonctionnement de deux chaînes de biosynthèse chez Saccharomyces cerevisiae: thréonine-méthionine et isoleucine-valine. Bulletin de la Société de ChimieBiologique, Paris 49:1431
    [Google Scholar]
  7. Derobichon-Szulmajster H., Cherest H. 1967; Regulation of homoserine-O-transacetylase, first steps in methionine biosynthesis in Saccharomyces cerevisiae . Biochemical and Biophysical Research Communications 17:265
    [Google Scholar]
  8. De Vito P. C., Dreyfus J. 1964; Metabolic regulation of adenosine triphosphate sulfurylase in yeast. Journal of Bacteriology 88:1341
    [Google Scholar]
  9. Herbert A. A., Guest J. R. 1968; Biochemical and genetic studies with lysine+methionine mutants of Escherichia coli:lipoic acid and α keto glutarate dehydrogenase less mutants. Journal of General Microbiology 53:363
    [Google Scholar]
  10. Kodaira R., Uemura T. 1960; On the production of hydrogen sulphide by yeast-on the role of pantothenic acid. Koso Kagaku Shinpoziumo 14:130
    [Google Scholar]
  11. Kodaira R., Ito Y., Uemura T. 1958; On the production of hydrogen sulphide by Saké yeast. I. Pantothenic acid deficiency and the production of hydrogen sulphide. Nippon Nôgei-Kagaku Kaishi 32:49
    [Google Scholar]
  12. Lawrence W. C., Cole E. R. 1968; Yeast sulphur metabolism and the formation of hydrogen sulphide in brewery fermentations. Wallerstein Laboratories Communications 31:95
    [Google Scholar]
  13. Nagai S., Flavin M. 1967; Acetylhomoserine: an intermediate in the fungal biosynthesis of methionine. Journal of Biological Chemistry 242:3884
    [Google Scholar]
  14. Naiki N. 1965; Some properties of sulphitereductase from yeast. Plant and Cell Physiology 6:179
    [Google Scholar]
  15. Okuda S., Uemura T. 1965; Sulphitereductase system of yeast in relation to pantothenic acid deficiency. Biochimica et Biophysica Acta 97:154
    [Google Scholar]
  16. Pigg C. J., Spence K. D., Parks L. W. 1962; Methionine biosynthesis in yeast. Archives of Biochemistry 97:491
    [Google Scholar]
  17. Rankine B. C. 1963; Nature, origin and prevention of hydrogen sulphide aroma in wines. Journal of the Science of Food and Agriculture 14:79
    [Google Scholar]
  18. Schlossmann K., Lynen F. 1957; Biosynthese des CysteinsausSerin und Schwefelwasserstoff. Biochemische Zeitschrift 328:591
    [Google Scholar]
  19. Wainwright T. 1962; Hydrogen sulphide formation by pantothenate deficient yeast. Journal of General Microbiology 28:v
    [Google Scholar]
  20. Wiebers J. L., Garner H. R. 1967; Acyl derivatives of homoserine as substrates for homocysteine synthesis in Neurosporacrassa, yeast and Escherichia coli . Journal of Biological Chemistry 242:5644
    [Google Scholar]
  21. Woods D. D. 1953; The integration of research on the nutrition and metabolism of micro-organisms. Journal of General Microbiology 9:151
    [Google Scholar]
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