SUMMARY: A new class of rough mutants has been found in both and The mutants resemble phenotypically mutants, having a complete lipopolysaccharide core but no O-specific material in lipopolysaccharide or as free hapten. The site of these mutations is near the isoleucine and valine gene and is thus separate from the known lipopolysaccharide gene clusters for the core, for the O-specific side-chains, and for O side-chain polymerization. The function of the gene(s) is not known. It is suggested that they might participate in the utilization of the antigen carrier lipid for lipopolysaccharide synthesis, or that they might regulate the activity of genes. The gene determining phosphorylation of the heptose in the lipopolysaccharide core of was identified as one within the cluster.


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