RT Journal Article SR Electronic(1) A1 Sriprakash, K. S. A1 Ramakrishnan, T.YR 1970 T1 Isoniazid-resistant Mutants of Mycobacterium tuberculosish 37 rv: Uptake of Isoniazid and the Properties of NADase Inhibitor JF Microbiology, VO 60 IS 1 SP 125 OP 132 DO https://doi.org/10.1099/00221287-60-1-125 PB Microbiology Society, SN 1465-2080, AB SUMMARY: Six independent isoniazid-resistant mutants of Mycobacterium tuberculosis were isolated under conditions which largely ensured the selection of one-step mutants. The properties of these mutants with respect to the nicotinamide adenine dinucleotide nucleosidase (NADase) inhibitor, isoniazid uptake and peroxidase activity were studied. The uptake of isoniazid by the mutants and their sensitivity to isoniazid were increased by ethylenediaminetetra-acetic acid (EDTA) and sodium dodecylsulphate. It is suggested that EDTA and sodium dodecylsulphate bring about these effects by altering the cell permeability., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-60-1-125