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Abstract
Some interactions of Aspergillus species with Staphylococcus aureus and Pseudomonas aeruginosa, all of which are concerned in otitis externa, are described. The pigments pyocyanine, 1-hydroxyphenazine and the fluorescent green pigments produced by P. aeruginosa inhibited the germination of spores of Aspergillus terreus; the most toxic of these pigments was 1-hydroxyphenazine. P. aeruginosa did not produce fluorescent pigments in Czapek-Dox medium unless the ferrous sulphate was omitted and asparagine added. Following incubation of the Aspergillus species in this medium, however, P. aeruginosa grew and produced fluorescent pigment therein. S. aureus produced antifungal toxic material which was capable of diffusing through cellophan and causing distortion of A. terreus hyphae.
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