1887

Abstract

SUMMARY

A single dose of -radiation to gave a semi-logarithmic dose-response curve. A second irradiation 3, 6, or 18 hr after a priming dose of 8 krad showed that the cells had become more radio-sensitive during the incubation between irradiations.

When mercaptoethylamine was present during irradiation, protection against the lethal effects of the -radiation occurred. After a priming dose to the bacteria in the presence of the radio-protective chemical, and incubations for 3,6, or 18 hr in its absence, a second irradiation in the absence of the chemical showed them to be much more radio-resistant than the normal unprotected . This indicates that the presence of the protector during irradiation alters the type of damage induced or the development and repair of that damage.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-57-1-97
1969-07-01
2024-04-24
Loading full text...

Full text loading...

/deliver/fulltext/micro/57/1/mic-57-1-97.html?itemId=/content/journal/micro/10.1099/00221287-57-1-97&mimeType=html&fmt=ahah

References

  1. Alper T., Moore J. L. 1967; The interdependance of oxygen enhancement ratio for 250 KVp X-rays and fast neutrons. Br. J. Radiol. 40:843
    [Google Scholar]
  2. Bacq Z. M. 1965 In Chemical Protection against Ionising Radiation: American Lecture Series New York: C. C. Thomas;
    [Google Scholar]
  3. Comroy H. L., Adler H. I. 1962; Influences of beta-mercaptoethylamine and oxygen removal on the X-ray sensitivities of four strains of Escherichia coli . J. gen. Microbiol. 28:431
    [Google Scholar]
  4. Dewey D. L., Boag J. W. 1959; Modification of oxygen effect when bacteria are given large pulses of radiation. Nature, Lond. 183:1450
    [Google Scholar]
  5. Elias C. A. 1961; The X-ray sensitivity of Escherichia coli in the presence of beta-mercaptoethylamine. Radiat. Res. 15:632
    [Google Scholar]
  6. Elkind M. M. 1966; Sublethal X-ray damage and its repair in mammalian cells. Radiation Research : Proceedings of Third International Congress of Radiation Research Silini G. Amsterdam: North-Holland Publishing Committee;
    [Google Scholar]
  7. Elkind M. M., Sutton H. 1959; X-ray damage and recovery in mammalian cells in culture. Nature, Lond. 184:1293
    [Google Scholar]
  8. Ginsberg D. M. 1966; Effects of beta-mercaptoethylamine on growth and radiation sensitivity of Escherichia coli strain 15 TAU-bar. Radiat. Res. 28:708
    [Google Scholar]
  9. Hernadi F., Valyi-Nagy T., Nagy Z. S., Seney A. 1962; Protection against the toxic effects of X-rays and nitrogen mustard on Escherichia coli 0 111 by radioprotectors. Radiat. Res. 16:464
    [Google Scholar]
  10. Hollaender A., Stapleton G. E. 1953; Fundamental studies of radiation protection from a microbiological point of view. Physiol. Rev. 33:77
    [Google Scholar]
  11. Howard-Flanders P., Alper T. 1957; The sensitivity of micro-organisms to irradiation under controlled gas-flow conditions. Radiat. Res. 7:518
    [Google Scholar]
  12. Kohn H. T., Gunter S. E. 1959; Factors influencing the radio-protective activity of cysteine: effects in Escherichia coli due to drug concentration, temperature, time and pH. Radiat. Res. 11:732
    [Google Scholar]
  13. Sinclair W. K. 1966; Radiation effects on mammalian cell populations in vitro . Radiation Research : Proceeding of the 3rd International Congress of Radiation Research Silini G. Amsterdam: North-Holland Publishing Committee;
    [Google Scholar]
  14. Stapleton G. E. 1955; Variations in the sensitivity of Escherichia coli to ionising radiations during the growth cycle. J. Bact. 70:357
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-57-1-97
Loading
/content/journal/micro/10.1099/00221287-57-1-97
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error