1887

Abstract

SUMMARY: strain 569H became resistant to tetracyclines, arsenite and cyanide. The degree of resistance acquired was independent of the inducing concentration up to 2 × 10 M. Recovery from tetracycline and arsenite inhibition involved a change in the bacteria themselves; cyanide resistance involved also the destruction of this inhibitory agent. Although there were many similarities between the tetracycline and arsenite recoveries, two distinct mechanisms were involved. Adaptation to tetracycline was not observed with or and did adapt to cyanide. Although polymyxin B was inactive by itself against lytic activity due to the antibiotic was seen when a tetracycline was also present in the medium. The lytic activity ceased when the bacilli recovered from tetracycline. did not adapt to other inhibitors of protein synthesis, RNA synthesis or oxidative phosphorylation.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-55-2-275
1969-02-01
2020-01-29
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-55-2-275
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error