1887

Abstract

SUMMARY: strain 569H became resistant to tetracyclines, arsenite and cyanide. The degree of resistance acquired was independent of the inducing concentration up to 2 × 10 . Recovery from tetracycline and arsenite inhibition involved a change in the bacteria themselves; cyanide resistance involved also the destruction of this inhibitory agent. Although there were many similarities between the tetracycline and arsenite recoveries, two distinct mechanisms were involved. Adaptation to tetracycline was not observed with or and did adapt to cyanide. Although polymyxin B was inactive by itself against lytic activity due to the antibiotic was seen when a tetracycline was also present in the medium. The lytic activity ceased when the bacilli recovered from tetracycline. did not adapt to other inhibitors of protein synthesis, RNA synthesis or oxidative phosphorylation.

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/content/journal/micro/10.1099/00221287-55-2-275
1969-02-01
2022-01-28
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References

  1. Connamacher R. H., Mandel H. H. 1964; Studies on the mechanism of action of tetracycline on B. cereus. . Fedn. Proc 23:388
    [Google Scholar]
  2. Connamacher R. H., Mandel H. G. 1968; Intracellular localization of tetracycline in bacteria. Biochim. biophys, Acta 166:475
    [Google Scholar]
  3. Connamacher R. H., Mandel H. G., Hahn F. E. 1966; Non-genetic resistance by Bacillus cereus to tetracycline. Fedn. Proc. Fedn. Am. Socs exp. Biol 25:344
    [Google Scholar]
  4. Connamacher R. H., Mandel H. G., Hahn F. E. 1967; Adaptation of populations of Bacillus cereus to tetracycline. Molec. Pharmac 3:586
    [Google Scholar]
  5. Coutsogeorgopoulos C. 1966; On the mechanism of action of chloramphenicol in protein syn- synthesis. Biochim. biophys, Acta 129:214
    [Google Scholar]
  6. Hash J. H., Wishnick M., Miller P. A. 1964; On the mechanism of action of the tetracycline antibiotics in Staphylococcus aureus. . J. biol. Chem 239:2070
    [Google Scholar]
  7. Jones J. G., Morrison G. A. 1962; The bacteriostatic actions of tetracycline and oxytetra-cycline. J. Pharm. Pharmac 14:808
    [Google Scholar]
  8. Lin S. Y., Mosteller R. D., Hardesty B. 1966; The mechanism of sodium fluoride and cyclo- hexamide inhibition of haemoglobin biosynthesis in the cell-free reticulocyte system. J. molec. Biol 21:51
    [Google Scholar]
  9. Mandel H. G., Mayersak J. S., Riis M. 1965; The action of arsenic on Bacillus cereus. . J. Pharm. Pharmac 17:794
    [Google Scholar]
  10. Matthews R. E. F., Smith J. D. 1956; Distribution of 8-Azaguanine in the nucleic acids of Bacillus cereus. . Nature; Lond.: 177271
    [Google Scholar]
  11. Nathans D.L, Lipmann F. 1961; Amino acid transfer from amino acylribonucleic acids to protein on ribosomes of Escherichia coli. . Proc. natn. Acad. Sci. U.S.A 47:497
    [Google Scholar]
  12. Newton B. A. 1956; The properties and mode of action of polymyxin. Bact. Rev 20:14
    [Google Scholar]
  13. Pestka S., Marshall R., Nirenberg M. 1965; RNA codewords and protein synthesis. V. Effect of streptomycin on the formation of ribosome-sRNA complexes. Proc. natn. Acad. Sci., U.S.A 53:639
    [Google Scholar]
  14. Reich E., Franklin R. M., Shatkin A. J., Tatum E. L. 1962; Action of actinomycin D on animal cells and viruses. Proc. natn. Acad. Sci. U.S.A 48:1238
    [Google Scholar]
  15. Wolfe A. D., Hahn F. E. 1964; Erythromycin: mode of action. Science, N.Y 143:1445
    [Google Scholar]
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