1887

Abstract

SUMMARY: Pairs of non-tetracycline-producing mutants of or were grown side by side on agar. Their ability to produce antibiotic by cosynthesis was tested by placing a strip of agar cut from the combined culture on plates containing . The activity was revealed as an inhibition halo formed on , opposite one or other mutant strain. The strain surrounded by the halo was considered as a converter of an intermediate product secreted by the other strain. Two types of mutants were observed: a rare type probably affecting the main pathway of antibiotic biosynthesis, and a more frequent type probably affecting some regulatory process.

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/content/journal/micro/10.1099/00221287-55-1-103
1969-01-01
2022-01-20
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References

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