SUMMARY: Thymidine kinase (EC, an enzyme that catalyses the phosphorylation of thymidine to thymidine-5′-phosphate in the presence of adenosine triphosphate and Mg, was not detected in cell-free extracts of or Deoxyribonucleic acid was not specifically labelled in grown in the presence of [C]thymidine, [C]thymidine monophosphate or [C]thymidine triphosphate. Instead, the isotope was incorporated into both types of nucleic acid in a ratio which approximated the mole ratio of ribonucleic acid to deoxyribonucleic acid. It is considered that the absence of thymidine kinase prevents the specific incorporation of thymidine into deoxyribonucleic acid in intact cells of


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