1887

Abstract

SUMMARY: The symptoms of tetanus in mice, resulting from intramuscular injection of either purified tetanus toxin or vegetative bacilli of , can be partially prevented if the mice are injected at the same time, or a few hours before or afterwards, with a preparation of mixed gangliosides or with a suspension of ganglioside/cerebroside complex. Injection at the same site as the toxin injection is most effective, although intravenous injection of ganglioside (but not of the complex) also has some action; 0.5 mg. of ganglioside when complexed with 1·5 mg. cerebroside is as effective in protection as 5 mg. ganglioside alone. Protection by complexes containing different proportions of ganglioside reflects their ability to fix tetanus toxin It is tentatively suggested that injection of ganglioside/cerebroside complex at a site of injury might be of prophylactic value in human tetanus.

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/content/journal/micro/10.1099/00221287-54-2-161
1968-12-01
2021-10-21
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